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KMID : 1189420070200010145
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 1 p.145 ~ p.153
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Study of Whakijogyung-Tang about cytotoxicity in S-180
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Kim Dae-Su
Choi Jung-Hwa
Kim Jong-Han
Park Su-Yeon
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Abstract
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Objecgtive: The aim of present study was to investigate inhibition effect of Whakijogyung-Tang(WJT) on the tumor cell lines. This study estimated the cytotoxicity of WJT about viability of S-180 and NlH3T3.
Methods: The cytotoxicity of WJT about viability of cells were tested using a colorimetric tetrazoliun assay(MTT assay)
Results and Conclusion: 1. Water extract of WJT had IC?? of 863 ug/ml in S-180 cell lines, but cytotoxicity of NIH3T3 was not significant difference compare with S-180. 2. n-Hexane fraction of WJT had similar cytotoxicity between S-180 and NIH3T3, but that could not have IC?? in S-180 cell lines. 3. Ethyl acetate fraction of WJT had low degree cytotoxicity both S-180 and NIH3T3 cell lines. 4. Significantly, Butanol fraction of WJT had differenct citotoxicity between S-180 and NIH3T3. 5. H₂O₂ fraction of WJT had no cytotoxicity both S-180 and NIH3T3.
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KEYWORD
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Whakijogyung-Tang(化氣調經湯), tumorcelllines, cytotoxicity
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